Antidepressants space the 3rd most typically prescribed drugs in the united States and are bring away by 11 percent that Americans age 12 years and over.

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Weight get is one of the potential side effects of antidepressant use, through some resources estimating the 25 percent of human being using antidepressants experience an increase in weight.

Although the reactions to particular antidepressants vary between individuals, some antidepressant medicines are an ext likely to result in weight obtain than others.

This write-up looks in ~ the connection in between weight gain and also antidepressant use.


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Share ~ above PinterestAntidepressants may result in weight gain as a human regains your appetite.
Experts do not fully understand why antidepressants cause weight gain in some people. One theory is the both metabolism and hunger levels might be affected.

Also, depression chin may reason weight get in some people and weight loss in others.

Antidepressants interfere v serotonin, the neurotransmitter that regulates anxiety and also mood while additionally controlling appetite. In particular, these alters may increase cravings for carbohydrate-rich foods, such together bread, pasta, and desserts.

When people are depressed, your appetites room affected. In part people, this might make lock hungrier while others lose their appetite. It may be the situation that when antidepressants take effect, someone’s usual appetite returns and this has an affect on their weight.

It should likewise be listed that depression can lead come fatigue and also inactivity, and also a lack of physical task can cause weight gain.

If a human is experiencing weight acquire while taking antidepressants, it may be one indication the the medicine is no combatting their depression effectively.


Also known as cyclic antidepressants, TCAs are some of the earliest develops of antidepressant medications.

They space not as typically prescribed together more modern-day forms that antidepressants, together they have the right to cause more side effects, consisting of weight gain. Enlarge research argues that extreme weight get caused numerous users come quit TCA treatment.

However, cyclic antidepressants can be effective, especially for some people who carry out not answers to various other treatments.

Examples that TCAs are:

amitriptyline (Elavil)amoxapinedesipramine (Norpramin)doxepin (Adapin)imipramine (Tofranil-PM)nortriptyline (Pamelor)protriptyline (Vivactil)trimipramine (Surmontil)

Monoamine oxidase inhibitors (MAOIs)

MAOIs are an additional early course of antidepressants and also have generally been replaced by newer antidepressant drugs. Return effective, they often tend to reason weight gain and also several other adverse reactions.

In addition, civilization who take MAOIs might need to restrict your diets, as these medicine can cause elevated blood press levels when taken through some foods and medications.

However, MAOIs assist relieve depression in some human being who do not see renovations with other drugs.

Types that MAOIs that may bring about weight acquire include:

isocarboxazid (Marplan)phenelzine (Nardil)tranylcypromine (Parnate)

One kind of MAOI referred to as selegiline (Emsam), a topical therapy that is applied to the skin together a patch, has been linked with weight loss in part users.

Selective serotonin reuptake inhibitors (SSRIs)

The most typically prescribed form of antidepressant medication, selective serotonin reuptake inhibitors (SSRIs) have been associated with load loss in short-term use, however may reason weight get when used long term.

Commonly supplied SSRIs include:

fluoxetine (Prozac)paroxetine (Brisdelle, Paxil, Pexeva)sertraline (Zoloft)

However, load gain associated with SSRIs counts on the size of time they space taken, as well as the type. Because that example, paroxetine is the most most likely to result in weight gain, if sertraline is least likely.

According to a 2017 study, SSRIs were connected with weight acquire when users involved in “unhealthy behaviours,” such together eating a standard Western diet, absence of exercise, and tobacco use.

Atypical antidepressants

One kind of atypical antidepressant referred to as mirtazapine (Remeron) has been attached to both increased appetite and weight gain. The is less likely, however, than TCAs to cause weight gain.


Not all antidepressants cause weight gain, and also some cause less weight get than other frequently prescribed medications.

Antidepressants linked with reduced levels of weight gain include:

escitalopram (Cipralex, Lexapro)levomilnacipran (Fetzima)nefazodone (Serzone)vortioxetine (Trintellix)

If offered on a momentary basis that fewer 보다 6 months, the following SSRIs are unlikely to reason weight gain:

citalopram (Celexa)fluoxetine (Prozac)sertraline (Zoloft)

In fact, part drugs supplied to act depression have been associated with weight loss, including:

bupropion (Aplenzin, Forfivo, Wellbutrin)selegiline (Emsam)

It is vital to seek help for depression, and also antidepressants room a highly effective treatment for numerous people. However, people should comment on the side effects of antidepressant medicines with their doctor prior to beginning treatment so they know what come expect.

People currently taking antidepressants have to let a doctor understand if lock experience any adverse reactions, consisting of weight gain.

If a human feels that the benefits of the medication, such as being able to manage the depression, outweigh the side effects, a doctor might advise them to deal with any weight get by dietary alters and an ext physical activity.

Research argues that exercise can improve mood and reduce depression. Also, it may be helpful to consult a dietician in order to come up through a suitable eating arrangement that will not adversely affect someone’s treatment.

A human may likewise talk to your doctor around adjusting the dose, or switching to an additional antidepressant to reduce side effects and manage weight. Sometimes, even switching to another antidepressant within the same class of drugs have the right to reduce symptoms.

It is important not come take any kind of weight loss drugs or supplements without consulting a doctor first, as they might interfere v the antidepressants.


While some antidepressants cause weight obtain in part people, they room an efficient treatment because that many human being with depression.

People taking antidepressant medications should speak to your doctor around any side results they experience, consisting of weight gain. For plenty of people, managing the depression will certainly take priority over shedding weight.

For part people, engaging in a healthier way of living in conjunction with antidepressant use, or convert to another antidepressant medication, may reverse the weight gain.

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A human being should always consult a doctor before making transforms to medications, diet, and levels of physical activity.